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Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid beta peptide. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Greater cognitive deterioration in women than men with Alzheimer's disease: a meta analysis. Drafting and critical revision of the manuscript for important intellectual content: All authors. Table 1 Study cohort characteristics. To measure whole brain amyloid deposition, a global cortex was defined as a union of orbital frontal, prefrontal, superior frontal, lateral temporal, parietal, posterior precuneus, occipital, anterior cingulate, and posterior cingulate. Global cortical amyloid SUVR was also included as a covariate in the upper results. In addition to genetics, sex is an important demographic factor that influences AD risk.

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